By C.B. Anfinsen, John T. Edsall, Frederic M. Richards, David S. Eisenberg and George Lorimer (Eds.)
Studies present themes within the box of protein chemistry. the themes lined contain the constitution and mechanism of heat-shock-related proteins, the position of prolylisomerases in protein folding, and the mechanism of enzymic and nonenzymic prolylcis-transisomerization.
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This function of prolyl isomerases in protein folding is the major topic of this review. Mechanistic aspects of the enzymes and the catalyzed reactions are described by Stein elsewhere in this volume. Here we discuss first the importance of prolyl isomerization reactions as slow, rate-limiting steps of folding and their interdependence with other events in protein folding. Then, experimental data on the catalysis by prolyl isomerases of various slow in vitro protein folding reactions are reviewed.
Accessory Folding Proteins by C.B. Anfinsen, John T. Edsall, Frederic M. Richards, David S. Eisenberg and George Lorimer (Eds.)