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By T.R. Flotte, and K.I. Berns (Eds.)

ISBN-10: 0444519491

ISBN-13: 9780444519498

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Additional info for Adeno-Associated Viral Vectors for Gene Therapy

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1982). Cloning of adeno‐associated virus into pBR322: Rescue of intact virus from the recombinant plasmid in human cells. Proc. Natl. Acad. Sci. USA 79, 2077–2081. Samulski, R. , Chang, L. S. and Shenk, T. (1989). Helper‐free stocks of recombinant adeno‐associated viruses: Normal integration does not require viral gene expression. J. Virol. 63, 3822–3828. Samulski, R. J. et al. (1991). Targeted integration of adeno‐associated virus (AAV) into human chromosome 19 [published erratum appears in EMBO J.

J. (1996). Second‐ strand synthesis is a rate‐limiting step for eYcient transduction by recombinant adeno‐associated virus vectors. J. Virol. 70, 3227–3234. Ferrari, F. , McCarty, D. and Samulski, R. J. (1997). New developments in the generation of Ad‐free, high‐titer rAAV gene therapy vectors. Nat. Med. 3, 1295–1297. Flotte, T. et al. (1996). A phase I study of an adeno‐associated virus‐CFTR gene vector in adult CF patients with mild lung disease. Hum. Gene Ther. 7, 1145–1159. Gao, G. P. et al.

S. and Shenk, T. (1991). Transcriptional repression by YY1, a human GLI‐Kruppel‐related protein, and relief of repression by adenovirus E1A protein. Cell 67, 377–388. Smith, R. H. and Kotin, R. M. (1998). The Rep52 gene product of adeno‐ associated virus is a DNA helicase with 30 ‐to–50 polarity. J. Virol. 72, 4874–4881. Ch. 2 PRODUCTION OF RESEARCH AND CLINICAL AAV 55 Smith, R. , Spano, A. J. and Kotin, R. M. (1997). The Rep78 gene product of adeno‐associated virus (AAV) self‐associates to form a hexameric complex in the presence of AAV ori sequences.

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